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Poster Session I Monday, December 08,
M1. Inflammation-induced Transcriptome and Anhedonia
Francis Lotrich*, Beverly French, Charles Ma, Marianne Seney, Etienne Sibille, George Tseng
Western Psychiatric Institute & Clinic, Pittsburgh, Pennsylvania
Background: Inflammatory cytokines, including interferon-alpha (IFN-α), are known to precipitate depression symptoms in humans. Many depression symptoms typically take several weeks to develop. However, only some individuals are vulnerable to this effect (∼25%), with most being resilient. We examined whether there would be similar variability in the behavioral effects of IFN-α in mice, and then explored associations between behavior and changes in gene transcription.
Methods:Behavioral results were collated using principal component analyses. After three weeks of daily injections, RNA from punch biopsies of brain tissue (frontal cortex/amygdala) and blood samples were then obtained and examined using Illumina microarrays. Differential expression was determined using LIMMA. With Ingenuity Canonical Pathway analyses, we explored associations of transcripts with behavior.
Results: Four behavioral factors were obtained, only one of which differed between vehicle and IFN-α. There was only a trend for increased anhedonic-l
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ACNP 55th Annual Meeting: Poster Session II
Sponsorship Statement: Publication of this supplement is sponsored by the ACNP.
Presenter disclosures are found within the abstracts. Disclosure Format: Company Name (Financial Contributor), Type of Financial Disclosure, Funding Received for Self or Spouse. Asterisks in the author lists indicate presenter of the abstract at the annual meeting.
T1. Brain Activation in Mid-Insula Dynamically Tracks Cardiorespiratory Interoception
Sahib Khalsa*, Mahlega Hassanpour, Qingfei Luo, Justin Feinstein, W Kyle Simmons, Jerzy Bodurka, Martin Paulus
Laureate Institute for Brain Research, Tulsa, Oklahoma, United States
Background: Interoceptive sensations, such as palpitations and dyspnea, are fundamental symptoms of panic anxiety. While leading theories emphasize key roles for the insular cortex in the central representation of interoceptive sensations, it is unclear whether this region responds dynamically to changes in cardiovascular state. To modulate cardiorespiratory afferent processing in healthy individuals we recently used bolus infusions of isoproterenol, a rapidly acting peripheral beta-adrenergic agonist similar to adrenaline. We observed dose-related increases in BOLD activation of the right mid dorsal insula (Hassanpo
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Rachel carson life gmc acadia
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